We are presenting with a rare and mysterious case of amyloidosis manifesting as cardiac arrhythmia a 52 year old male who was admitted at the Philippine Hear Center. The patient succumbed to death on the second hospital day. A partial autopsy was done which revealed amyloid deposits in five different organs, namely the heart, liver, pancreas, kidney and lungs. Variability in tissue distribution and volume of amyloid deposits occur in different individuals and no signs and symptoms are characteristic of this condition. the clinical presentation of the patient is determined by the principal site of amyloid deposition. In this case symptomatic cardiac amyloidosis has infiltrated and affected the conduction system-main;y sino-atrial (SA) and atrioventricular (AV) nodes of the heart. Hence, impairing ventricular contraction and relaxation, and developing cardiac arrythmia.